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喘儿童的益生菌:系统审查和元分析
Yang Liu1,2,3,4, Yuxiao Zhang1,2,3,4, Yingna Li1,2,3,4
1Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China.
Frontiers in pediatrics
|May 9, 2025
概括
益生菌补充剂可以帮助减少儿童的喘发作,改善肺功能. 需要进一步的研究来确认儿童喘管理的最佳使用.
科学领域:
- 儿科肺病学 儿科肺病学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 喘是全球儿童普遍存在的慢性炎症性呼吸道疾病.
- 益生菌在治疗儿科喘中的作用目前仍在争论中.
- 现有的研究对益生菌的有效性提出了相互矛盾的证据.
研究的目的:
- 在被诊断患有喘的儿童中系统评估益生菌干预措施的有效性.
- 综合儿童喘和益生菌随机对照试验 (RCT) 的研究结果.
- 为临床实践和未来研究方向提供基于证据的摘要.
主要方法:
- 在主要数据库 (PubMed, Web of Science, Embase, CENTRAL) 和clinicaltrials.gov.gov进行了全面的系统搜索.
- 包括2014年至2024年期间发表的涉及患有喘的儿童和益生菌干预的随机对照试验 (RCT).
- 数据分析涉及对主要结果的元分析:喘恶化率和预测的FEV1/FVC比率,使用Cochrane指南进行偏差风险评估.
主要成果:
- 八个带有902名参与者的RCT被纳入了元分析.
- 益生菌显著减少了急性喘发作 (风险比:0.38,p < 0.00001).
- 在FEV1/FVC比率 (平均差异:5.70,p < 0.003) 中观察到显著改善,但在FEV1水平或上学率中没有明显改善.
结论:
- 益生菌补充剂显示出降低喘恶化和增强小儿喘患者肺功能的潜力.
- 研究中的显著异质性需要进一步调查最佳益生菌菌株,剂量和治疗持续时间.
- 本综述为儿童呼吸道疾病的微生物干预提供了基础的见解.
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