在秘鲁和肯尼亚的Mycobacterium结核病暴露群体中长期COVID的患病率
Asiko Ongaya1, Ariana R Cardenas2,3, Clement Shiluli4
1Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.
概括
长期COVID症状在秘鲁很普遍,影响了40%以上的参与者,神经和肌肉骨问题很常见. 然而,肯尼亚的医疗保健工作者报告没有长期COVID症状,表明需要进一步研究地理和并发性影响.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 长期COVID (LC) 症状在SARS-CoV-2感染后持续超过三个月.
- 低收入和中等收入国家中LC的患病率及其与结核病 (TB) 等共感染的相互作用尚未得到充分了解.
- 这项研究调查了秘鲁和肯尼亚暴露于*Mycobacterium tuberculosis* (Mtb) 的群体中的LC.
研究的目的:
- 确定秘鲁和肯尼亚结核病暴露人口中长期COVID (LC) 的患病率和临床特征.
- 探索与*Mycobacterium tuberculosis* (Mtb) 共同感染对LC发育和症状的影响.
- 评估患有COVID-19后症状的个体的生活质量.
主要方法:
- 在秘鲁招募的未感染艾滋病毒的肺结核患者和家庭接触者 (n=99).
- 在肯尼亚招募的医疗保健工作者 (n=202).
- 在SARS-CoV-2诊断后两年内使用标准化仪器收集临床数据.
主要成果:
- 在秘鲁,41.4%的人报告了LC症状,主要是神经和肌肉骨;结核病状态没有显著改变LC患病率或表型.
- 肯尼亚参与者报告了急性症状,但否认LC,尽管他们在急性感染期间生活质量下降.
- 在秘鲁,LC与除抑郁和焦虑之外的所有生活质量维度的显著下降有关.
结论:
- 长期COVID的流行率在秘鲁很高,神经和肌肉骨症状是最常见的,无论结核病状况如何.
- 肯尼亚的医疗保健工作者意外地报告说没有LC症状,突出了地理和人口特异性的差异.
- 进一步的长期跟踪和更大,多样化的研究至关重要,以了解结核病共发病对长期COVID的影响.
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