分享的运动和感知激活对神经假体解码的感觉运动皮质的影响
概括
这项研究开发了一种语音神经假体,可以从感觉运动皮质准确地解码预期的语音,即使在阅读和听力过程中也是如此. 该系统保持了对意志性言语的特异性,这对于日常沟通恢复至关重要.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 语音科学 语言科学
背景情况:
- 神经假体旨在通过解码来自感觉运动皮层 (SMC) 的语音意图,恢复患者的沟通.
- SMC涉及运动和感知功能,这引发了关于在阅读和倾听等日常活动中对语音解码的潜在干扰的问题.
研究的目的:
- 为神经假体开发和评估基于电皮质谱 (ECoG) 的语音解码系统.
- 为了评估系统的准确性和特异性在并发的语音,阅读和听力任务.
- 研究SMC中语音,阅读和听力的神经表示.
主要方法:
- 为两名声道的参与者开发了一个基于ECoG的在线语音解码系统.
- 在尝试语音和感知任务 (阅读,倾听) 中测试了系统的性能.
- 对光谱时间特征和神经反应的空间分布进行了离线分析.
主要成果:
- 语音解码系统在日常任务中保持了对预期语音的准确性和特异性.
- 在63.2分钟的言语和感知任务尝试中,观察到零个虚假阳性激活.
- 在中部前中心环中共享的神经群体对言语,听力和阅读做出了反应,但具有可差异化的光谱时间反应.
结论:
- 开发的解码框架证明了可靠的语音神经假体,在日常活动中保留了对意志性语音尝试的特异性.
- 这项研究促进了SMC内部共享感知和运动活动的理解.
- 这些发现支持为无关节症患者开发实用的神经假体通信系统.
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