从模拟的纵向数据计算流行病学结果
Selina Pi1, Jeremy D Goldhaber-Fiebert2, Fernando Alarid-Escudero2
1Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA, USA.
概括
微模拟模型现在可以从长期的个人数据计算流行病学结果. 本报告提供了方法和R代码,用于准确的人口水平健康指标,增强模型验证.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
- 计算生物学 计算生物学
背景情况:
- 微型模拟模型生成个人生命轨迹,用于人口层面的分析.
- 从长期纵向数据计算流行病学结果是具有挑战性的,因为数据稀有.
- 现有的公式对于涵盖人类寿命的长期研究是有限的.
研究的目的:
- 提出利用模拟纵向数据计算流行病学结果的方法.
- 为计算各种人口水平健康指标提供开源R代码.
- 提高微模拟模型结果报告的透明度.
主要方法:
- 从模拟的纵向数据开发了计算流行率,发病率和终身风险的方法.
- 将纵向疾病和暴露时间纳入结果计算.
- 创建了一个开源的R代码库,用于计算流行病学和癌症相关结果.
主要成果:
- 提供了计算流行率,发病率,年龄条件风险,终身风险和疾病特异性死亡率的功能.
- 为癌症特异性结果提供指导和代码,如阶段分布和病变多重性.
- 证明了计算平均居住和逗留时间的方法.
结论:
- 该报告有助于从模拟和真实世界的纵向数据计算流行病学结果.
- 在报告微模拟模型的结果推导方面提高透明度至关重要.
- 提供的R代码和方法支持可靠的模型校准和验证.
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