自由三甲基氨酸和甘油三糖指数的相互作用,对在euthyroid个体的代谢功能障碍相关的脂肪性肝病风险
相关实验视频
Updated: May 12, 2025
08:58
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
15.8K
Lei Gao1, Wenxia Cui1, Fenghui Pan1
1Department of Geriatrics, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Frontiers in endocrinology
|May 9, 2025
概括
增加的自由三甲氨酸 (FT3) 和甘油三糖 (TyG) 指数与与代谢功能障碍相关的脂肪肝疾病 (MASLD) 的更高风险有关. 这些因素显示出结合作用,增加了MASLD在euthyroid个体的可能性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 肝病学 肝病学是一种肝病学.
背景情况:
- 人们越来越认识到甲状腺激素,胰岛素抵抗和MASLD之间的相互作用.
- 由于甲状腺激素的变化,优甲状腺个体可能仍然面临MASLD的风险.
- 了解这些联系对于代谢性疾病管理至关重要.
研究的目的:
- 为了研究自由三甲氨酸 (FT3) 水平与甘油三糖 (TyG) 指数之间的关联.
- 确定FT3和TyG指数对非甲状腺体患者患MASLD的风险的影响.
主要方法:
- 这是一项对18298名甲状腺功能良好的个体 (6,144名MASLD,12,154名对照) 的横截面研究.
- 分析包括临床,代谢和甲状腺功能指标.
- 后勤回归评估了FT3和TyG指数对MASLD概率的综合影响.
主要成果:
- 更高的FT3和TyG指数独立地与增加的MASLD风险有关.
- 调整后的赔率比:FT3 (1.35) 和TyG指数 (3.99).
- 观察到一种协同作用;高FT3/高TyG组具有显著更高的MASLD风险 (OR = 5.38).
结论:
- 高FT3和TyG指数是MASLD的独立风险因素.
- 在高FT3和高TyG指数之间存在显著的协同增益相互作用,增加了MASLD风险.
- 这些发现强调了监测甲状腺功能和代谢标志物的重要性,以预防MASLD.
更多相关视频
07:12Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
Published on: June 2, 2023
5.9K
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
683
相关概念视频
01:24Overview of Lipid Metabolism
849
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
849
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
103
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
103
01:20Synthesis and Regulation of Thyroid Hormones
3.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
3.9K
01:30Liver Physiology
382
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
382
01:19Overview of Carbohydrate Metabolism
551
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
551
01:24Obesity
338
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
338