认知功能和皮质厚度之间的关系在第一期药物原始精神分裂症患者与激动
Qian Liang1, Yan Li1, Chao Zhou1
1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Frontiers in psychiatry
|May 9, 2025
概括
第一次药物原始精神分裂症 (FESN) 中的激动与右后带状皮层 (rPCC) 异常厚度和工作记忆障碍有关. 这表明rPCC是治疗精神分裂症激动和认知缺陷的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 精神分裂症是一种复杂的精神障碍,其特点是认知缺陷和行为障碍.
- 兴奋是精神分裂症的常见和令人痛苦的症状,影响患者的护理和结果.
- 了解精神分裂症早期动荡和认知功能障碍的神经生物学基础对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究激动,认知功能和皮质厚度之间的关系,在第一个情节的药物原始精神分裂症 (FESN).
- 在FESN中识别激动和认知障碍的潜在神经解剖相关物.
- 探索后带状皮质 (PCC) 在精神分裂症激动的病理生理学中的作用.
主要方法:
- 招募了79名患有FESN的男性住院患者和55名男性健康对照 (HC).
- 使用 MATRICS 共识认知电池 (MCCB) 评估认知功能.
- 使用Freesurfer测量T1权重的MRI的全脑皮层厚度;根据PANSS-EC得分将FESN患者分为激动 (FESN+A) 和非激动 (FESN+NA) 组.
主要成果:
- 两组FESN在多个领域都表现出比HC更差的认知表现.
- 与FESN+NA组相比,FESN+A组表现出更差的工作记忆和更厚的右后带状皮层 (rPCC).
- 在FESN+A组中,rPCC皮质厚度与工作记忆得分有负相关性.
结论:
- 异常的rPCC皮质厚度与FESN中的激动和工作记忆缺陷有关.
- 这些发现表明,rPCC可能在精神分裂症中兴奋和认知障碍的病理生理学中发挥作用.
- 在FESN中,rPCC变化代表了管理激动和认知功能障碍的潜在治疗目标.
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