循环炎症生物标志物的预测价值,用于早期发作的中风后认知障碍:一项前性队列研究
Weiquan Huang1, Libin Liao1, Qian Liu2
1Department of General Practice, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Frontiers in neurology
|May 9, 2025
概括
早期中风患者血球蛋白与淋巴细胞比率 (GLR) 升高预示着中风后认知障碍 (PSCI). 这种免疫炎症标记可能有助于识别患中风后认知能力下降的风险较高的人.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 在全球范围内,中风是导致死亡和残疾的主要原因.
- 脑卒中后认知障碍 (PSCI) 是急性缺血性中风的常见并发症,对患者和社会产生重大影响.
- 识别可靠的PSCI预测指标对于及时干预和管理至关重要.
研究的目的:
- 调查循环免疫炎症标志物作为早期发病PSCI的预测剂的潜力.
- 确定特定免疫细胞比率与PSCI发展之间的关联.
- 评估全球蛋白与淋巴细胞比率 (GLR) 作为PSCI的独立预测指标.
主要方法:
- 一项前性观察队列研究,涉及146名首次急性缺血性中风患者.
- 使用蒙特利尔认知评估 (MoCA) 评估中风后7-10天的认知功能.
- 分析了周围血液的免疫炎症标志物,包括中性粒细胞与淋巴细胞的比率 (NLR),全球蛋白与淋巴细胞的比率 (GLR),C反应蛋白与淋巴细胞的比率 (CLR) 和淋巴细胞与单细胞的比率 (LMR).
主要成果:
- 71名患者 (48.6%) 患有PSCI.
- 与没有认知障碍的患者相比,PSCI患者的NLR,GLR和CLR显著更高,LMR较低 (p <0.05).
- 多变量分析确定GLR是PSCI的独立预测因子 (OR = 6.20; p = 0.001),最佳切线为18.22 (AUC = 0.726).
结论:
- 在中风后急性阶段循环GLR水平升高是PSCI早期发作的独立风险因素.
- GLR作为一个有价值和可访问的生物标志物,用于预测缺血性中风后的认知障碍.
- 这些发现支持GLR在临床实践中用于PSCI风险分层的使用.
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