Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bonferroni Test01:10

Bonferroni Test

2.7K
The Bonferroni test is a statistical test named after Carlo Emilio Bonferroni, an Italian mathematician best known for Bonferroni inequalities. This statistical test is a type of multiple comparison test to determine which means are different than the rest. Bonferroni test can minimize the Type 1 error by reducing the significance level alpha, which otherwise increases with sample pairs.
The means of different samples are first paired in all possible combinations.
The null hypothesis of the...
2.7K
Multiple Comparison Tests01:13

Multiple Comparison Tests

3.8K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
3.8K
Comparing Experimental Results: Student's t-Test01:09

Comparing Experimental Results: Student's t-Test

1.4K
The t-test is a statistical method used to compare the sample mean with a population mean or compare two means from two data sets. The test statistic is calculated from the standard deviation, mean, and number of measurements in the data set at a selected confidence interval and then compared to a table of critical values at this confidence level. If the test statistic is smaller than the critical value, the null hypothesis is accepted. In this case, we state that the difference between the...
1.4K
Types of Hypothesis Testing01:11

Types of Hypothesis Testing

26.0K
There are three types of hypothesis tests: right-tailed, left-tailed, and two-tailed.
When the null and alternative hypotheses are stated, it is observed that the null hypothesis is a neutral statement against which the alternative hypothesis is tested. The alternative hypothesis is a claim that instead has a certain direction. If the null hypothesis claims that p = 0.5, the alternative hypothesis would be an opposing statement to this and can be put either p > 0.5, p < 0.5, or p...
26.0K
Sign Test for Matched Pairs01:17

Sign Test for Matched Pairs

86
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
86
Decision Making: Traditional Method01:14

Decision Making: Traditional Method

3.9K
The process of hypothesis testing based on the traditional method includes calculating the critical value, testing the value of the test statistic using the sample data, and interpreting these values.
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pilot Study: Vancomycin Calcium Sulfate Beads in the Prevention of Recurrent Capsular Contracture of Breast Implants.

Plastic and reconstructive surgery. Global open·2026
Same author

Test-Negative Designs With Multiple Testing Sources.

Statistics in medicine·2026
Same author

Constructing a Literature-Derived Database for Benchmarking Polygenic Risk Score Construction Methods with Spectral Ranking Inferences.

medRxiv : the preprint server for health sciences·2026
Same author

Test-negative Designs with Various Reasons for Testing: Statistical Bias and Solution.

Epidemiology (Cambridge, Mass.)·2025
Same author

RANDOMIZATION INFERENCE FOR CLUSTER-RANDOMIZED TEST-NEGATIVE DESIGNS WITH APPLICATION TO DENGUE STUDIES: UNBIASED ESTIMATION, PARTIAL COMPLIANCE, AND STEPPED-WEDGE DESIGN.

The annals of applied statistics·2025
Same author

Spatiotemporal effects on dengue incidence based on a large cluster randomized study.

Statistical methods in medical research·2025
Same journal

HIV Transmission Dynamics in Greater Mexico City are Shaped by Dense Spatial Mixing.

Research square·2026
Same journal

A UCP1-IRES-Cre Knock-In Mouse Enables Specific Brown Adipocyte Targeting Without CNS Off-Target Expression.

Research square·2026
Same journal

Precision RNAi for Fibrodysplasia Ossificans Progressiva: a combinatorial, unimolecular, allele selective approach.

Research square·2026
Same journal

Perceptions of end-of-life care quality among bereaved closest contacts of community-dwelling older Australians: a cross-sectional survey of the ASPREE cohort.

Research square·2026
Same journal

Heavy-chain immune repertoire sequencing enables language-model prediction of antigen-specific antibodies.

Research square·2026
Same journal

25+ Years of TRPV4: From Discovery to Translational Horizons.

Research square·2026
查看所有相关文章

相关实验视频

Updated: May 20, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

具有多个测试源的测试负面设计.

Mengxin Yu1, Nicholas P Jewell2

  • 1Department of Statistics and Data Science, University of Pennsylvania, PA, United States.

Research square
|May 9, 2025
PubMed
概括
此摘要是机器生成的。

试验负的设计有效地评估疫苗的疗效. 这项研究解决了多种测试原因的偏见,提出了埃博拉疫苗试验的方法,以确保准确的疗效评估.

关键词:
一个案例-队列研究.埃博拉病毒埃博拉病毒.测试负面的设计.

更多相关视频

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
00:08

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

6.9K
Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

3.8K

相关实验视频

Last Updated: May 20, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
00:08

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

6.9K
Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

3.8K

科学领域:

  • 流行病学 流行病学
  • 疫苗学 疫苗学 疫苗学
  • 生物统计学 生物统计学

背景情况:

  • 测试阴性设计 (TND) 是用于评估像疫苗这样的传染病干预措施的常见方法.
  • 传统上,TND通过测试有症状的个体来减少从寻求医疗保健行为中引起的混.
  • 最近的挑战包括聚合症状和无症状测试结果的偏见,特别是对于COVID-19和埃博拉等疾病.

研究的目的:

  • 解决TND中"测试问题的多个原因"的问题.
  • 提出一种方法来估计疫苗的疗效,使用综合的症状和无症状测试结果.
  • 评估疫苗的疗效是否在不同的测试来源中一致.

主要方法:

  • 在埃博拉病毒病 (EVD) 疫苗试验中使用了修改后的TND方法.
  • 综合测试的密切接触的症状,测试阳性个体.
  • 从双重测试来源开发了一种统计方法来估计常见的疫苗疗效.

主要成果:

  • 该研究提出了一种方法,通过症状和无症状病例来估计疫苗的疗效.
  • 这种方法可以评估这些两组之间的疗效是否有所不同.
  • 虽然EVD试验提前结束,但该方法对于未来的疫苗疗效研究仍然很重要.

结论:

  • 一种精细的TND方法可以减轻多种测试原因的偏差.
  • 准确评估疫苗的疗效需要考虑各种不同的测试场景.
  • 拟议的方法对于未来的传染病疫苗试验至关重要,尤其是在疫情爆发期间.