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儿童器官供应流程 (cOOPS):了解传染性风险评估和缓解策略
Trinity Lee1, Katya Prakash2, Hannah Bahakel1
1Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.
Pediatric transplantation
|May 9, 2025
概括
儿童传染病临床医生在接受有SARS-CoV-2等常见感染的捐赠器官方面表现出强烈的共识,但对于更罕见的病原体存在较少的共识. 移植后管理和捐赠者检测的实践模式各不相同,这表明需要改善儿科器官移植的教育和研究.
科学领域:
- 儿童传染病 儿童传染病
- 固体器官移植 实体器官移植
- 感染控制 感染控制
背景情况:
- 儿科传染病 (PID) 临床医生评估在固体器官移植中提供捐赠器官的感染风险.
- 现实生活场景的当前实践模式没有得到很好的描述.
研究的目的:
- 描述PID临床医生关于捐赠器官接受和移植后干预的实践模式.
- 确定儿科器官供应的决策领域的共识和变化.
主要方法:
- 一项调查通过3个PID特定的listservs.com分发给PID临床医生.
- 12个虚构的儿科病例场景被用于评估器官接受和移植后干预.
- 用描述性统计数据来分析调查数据.
主要成果:
- 观察到接受梅毒,SARS-CoV-2,MRSA,大肠杆菌,结核病 (肝脏) 和犀牛/肠道病毒的器官的高度一致 (>80%).
- 较低的协议被发现的器官有风险的菌菌,查加斯病,多药耐药的Acinetobacter baumannii和流感.
- 在移植后监测,抗微生物药物管理和针对特定感染的供体检测 (如SARS-CoV-2,MRSA和查加斯病) 中存在差异.
结论:
- 虽然对于许多儿科器官供应场景存在共识,但对当前建议的加强教育可以改善决策.
- 管理的变化突出了教育和研究的机会,以优化针对儿科接受者的捐赠源感染的策略.
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