鉴定sinigrin作为强奸花粉的活性化合物,用于通过PI3K/AKT/mTOR轴治疗良性前列腺增生
Bingliang Chen1,2, Yingchao Wang3, Guoda Song1
1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Phytotherapy research : PTR
|May 9, 2025
概括
花粉提取物通过PI3K/AKT/mTOR通路激活自,有效治疗良性前列腺增生 (BPH). 辛格林被确定为BPH治疗中这些治疗效果的主要活性化合物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 良性前列腺增生症 (BPH) 是老年男性中普遍存在的疾病.
- 由强奸花粉 (RP) 制成的PuleanPian是一种成熟的BPH药物.
- 在BPH治疗中RP的活性化合物和机制仍然未确定.
研究的目的:
- 确定强奸花粉 (RP) 中的主要活性化合物,负责治疗良性前列腺增生症 (BPH).
- 阐明RP对BPH的治疗效果背后的分子机制.
主要方法:
- 在老鼠模型中使用雌激醇/ (E2/T) 诱导BPH,然后用RP或其酒精提取物 (ALRP) 进行治疗.
- 应用RNA测序 (RNA-seq) 和代谢学来进行综合分析.
- 使用液态染色体质谱法 (LC-MS) 识别RP化合物,并用BPH-1和RWPE-1细胞进行体外验证.
主要成果:
- 在大鼠中,RP和ALRP治疗显著缓解了E2/T诱导的BPH症状.
- RP的使用与酸-3-酶 (PI3K) /AKT通路的激活有关,促进了自.
- 液体染色体质谱学 (LC-MS) 确定了RP中的五种主要化合物,其中sinigrin通过PI3K/AKT/哺乳动物目标的拉巴胺素 (mTOR) 信号通路在BPH治疗中具有强烈的影响.
结论:
- 辛格林被提议作为强奸花粉 (RP) 中的关键活性化合物,用于治疗良性前列腺增生 (BPH).
- 西尼格林在BPH中的治疗作用涉及PI3K/AKT/mTOR途径的调节和自的促进.
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