在ART周期中,GnRH主激素触发对随后的卵泡相位长度的影响
Roza Berkovitz-Shperling1, Yaara Libai2, Shir Aviv2
1Department of Obstetrics and Gynecology, Lis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Faculty of Medicine, Tel Aviv University, 6 Weizman St., 6423906, Tel Aviv, Israel. raz.bershp@gmail.com.
Journal of assisted reproduction and genetics
|May 9, 2025
概括
使用激素释放激素 (GnRH) 激素激素触发器用于最终卵细胞成熟,与人类胆管激素 (hCG) 触发器相比,可显著延长卵泡阶段. 这种方法不会对接受生育治疗的妇女的怀孕率产生负面影响.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
背景情况:
- 控制性卵巢刺激方案旨在优化卵细胞检索和随后的怀孕率.
- 选择触发药物,如GnRH激动剂或hCG,可以影响荷尔蒙环境和卵巢反应.
- 了解触发器选择对质期和随后的周期事件的影响,对于个性化生育护理至关重要.
研究的目的:
- 调查使用GnRH主激素触发剂与hCG触发剂是否会影响接受生育治疗的女性随后的卵泡期的长度.
- 为了确定触发药物的选择是否会影响周期中的怀孕率,使用一种结所有策略来进行单一性疾病的植入前遗传测试 (PGT-M).
主要方法:
- 一项回顾性队列研究包括196名接受受控卵巢刺激的妇女,使用PGT-M的所有结策略.
- 参与者被分为两组:132人接受了GnRH激动剂触发剂,64人接受了hCG触发剂.
- 包括多重回归在内的统计分析被用来比较群体之间的卵泡期长度和怀孕率,并调整了潜在的混因素,如BMI.
主要成果:
- 与hCG触发组 (16.06天) 相比,GnRH主动激素触发组表现出明显更长的随后的卵泡阶段 (18.98天) (P < .001).
- 延长的卵泡阶段发生在90.2%的GnRH激动剂周期和60.9%的hCG周期 (P < .001).
- 鉴定出GnRH激素激活因子和BMI是卵泡期长度的独立预测因子,两组妊娠率相似 (P=.173).
结论:
- 与hCG触发剂相比,GnRH激动剂触发剂会延长随后的卵泡期,而不会影响怀孕的结果.
- 身体质量指数 (BMI) 显示出与卵泡阶段长度的统计学上显著但适度的关联,需要进一步调查.
- 这些发现表明,GnRH激素激活剂可以优化冷胚胎移植的时间,并支持在生育治疗中的个性化监测协议.
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