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Updated: May 12, 2025

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在婴儿期因RSV感染而导致的抗生素使用 - - 国际前性出生队列研究

Sarah F Hak¹, Roderick P Venekamp², Marie-Noëlle Billard¹

¹Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.

The Journal of antimicrobial chemotherapy

|May 9, 2025

概括

大约1.3%的婴儿在第一年内接受抗生素治疗呼吸道同胞病毒 (RSV) 感染. 这突显了RSV对早期抗生素暴露和抗菌素耐药性的重大影响.

科学领域:

儿科儿科儿科
传染性疾病传染性疾病
微生物学微生物学

背景情况:

早期的抗生素暴露会影响微生物群的发展和抗菌素耐药性.
呼吸道同胞病毒 (RSV) 是导致婴儿急性呼吸道感染 (ARI) 的主要原因之一.
关于专门与婴儿RSV相关的抗生素使用的数据有限.

研究的目的:

量化与RSV感染相关的抗生素使用在婴儿生命的第一年.

主要方法:

一项前性出生队列研究 (RESCEU) 追踪了五个欧洲国家的9154名婴儿.
在RSV季节期间,在993名婴儿的嵌套队列中,使用鼻进行了RSV积极监测.
抗生素使用记录通过医疗病历审查住院和门诊护理的家长问卷.

主要成果:

抗生素在RSV住院病例的22.8%和RSV重症监护病例的62.5%中使用.
在嵌套队列中,所有RSV-ARI的5.2%和医疗护理的RSV-ARI的9.9%接受了抗生素.
估计1.3%的健康的婴儿在第一年接受了RSV感染的抗生素,占RSV季节ARI抗生素处方的22.9%.

结论:

77名健康婴儿中有1名在1岁之前接受了RSV感染的抗生素.
需要进一步研究RSV免疫对婴儿抗生素使用的影响.

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