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Updated: May 12, 2026

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
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一种新的纳米乳液人工眼在干眼疾病管理中的有效性:为前性队列研究研究的研究协议

Xulin Liao1,2, Biyue Guo1, Jingfang Bian2,3

  • 1Centre for Eye and Vision Research (CEVR), Shatin, Hong Kong SAR, China.

PloS one
|May 9, 2025
PubMed
概括

这项研究评估了Systane COMPLETE多剂量无防腐剂 (MDPF) 眼药,用于亚洲患者的轻度至中度干眼病 (DED). 结果可能为干眼症状缓解提供新的治疗选择.

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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...