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Updated: May 22, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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人类TWIK-2通道的结构及其通过皮莫齐德的抑制

Nandish K Khanra1, Chongyuan Wang1, Bryce D Delgado1,2

  • 1Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Proceedings of the National Academy of Sciences of the United States of America
|May 9, 2025
PubMed
概括

通道TWIK-2,对于炎症酶激活至关重要,其结构由冷EM揭示. 药物皮莫齐德直接抑制TWIK-2,提供一种潜在的抗炎治疗策略.

关键词:
在 K2P 频道中使用 K2P.在K2P6中,K2P6是K2P6.在NLRP3炎症酶体中,NLRP3炎症通道是一种通道.这是一种治疗疗法.

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