发现3 - - 伊米达佐利尔 - 皮里达衍生物作为具有抗瘤活性的强有力的刺痛激动剂

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Hui Hou1,2, Jingyi Zhou3,4, Qibang Sui1,2

  • 1Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Journal of medicinal chemistry
|May 9, 2025
PubMed
概括

研究人员发现了新型的3 - - 胺醇) 化衍生物,作为干扰素基因 (STING) agonists的强有力的刺激剂. 化合物A4通过有效激活STING和在临床前模型中减少瘤大小,显示出瘤免疫疗法的显著潜力.

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