慢性疼痛中与压力相关的大脑变化
Yann Quidé1,2, Negin Hesam-Shariati1,2, Nell Norman-Nott1,2
1NeuroRecovery Research Hub, School of Psychology, UNSW Sydney, Sydney, New South Wales, Australia.
European journal of pain (London, England)
|May 9, 2025
概括
在慢性疼痛患者和健康人群中,压力严重程度会对大脑结构产生不同的影响. 较高的压力缩小了患者的关键疼痛处理区域,而在健康的对照人群中,它扩大了它们,表明了弹性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 慢性疼痛经常与压力症状同时发生.
- 压力和慢性疼痛都会影响大脑形态.
- 压力严重程度,慢性疼痛和大脑结构之间的确切关系尚不清楚.
研究的目的:
- 研究压力严重程度如何影响慢性疼痛患者的灰质体积,与无疼痛对照人群相比.
- 为了澄清慢性疼痛,压力水平和特定大脑区域之间的相互作用.
主要方法:
- 用T1权重磁共振成像 (MRI) 对52名慢性疼痛患者和38名健康对照 (HC) 使用.
- 使用创伤后应激障碍检查清单 (PCL-C) 评估压力症状严重程度.
- 多重线性回归分析了群体的影响,压力严重程度 (总和症状特异性得分),以及它们对区域灰质体积的相互作用.
主要成果:
- 压力严重程度与群体状况有显著的相互作用,影响左/右膜,左中环皮层 (MCC) 和右后侧胰岛的灰质体积.
- 在慢性疼痛患者中,较高的压力与较小的左侧/右侧门和较大的左侧MCC/右侧后腹岛有关.
- 在HC中,较高的应力与较大的左/右门和较小的左MCC/右后半岛相相关.
结论:
- 压力严重程度作为慢性疼痛相关的结构性大脑变化的调节者.
- 增加的压力,特别是避免症状,与慢性疼痛患者的左侧MCC较小有关.
- 研究结果表明,与健康状态相比,慢性疼痛中压力反应背后存在着不同的神经机制.
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