动脉硬,中央血压,以及高血压成年人中意外中风的风险
Tianyu Cao1,2, Zaihua Cheng1, Yaping Wei3
1Department of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
European journal of neurology
|May 9, 2025
概括
患有高心血压 (cSBP) 和动脉硬 (cfPWV) 的高血压患者面临明显增加的中风风险. 量身定制的治疗策略对于管理这种高风险至关重要.
科学领域:
- 心血管医学 心血管医学
- 高血压研究 高血压研究
- 预防中风 预防中风
背景情况:
- 动脉硬和中央缩血压 (cSBP) 是高血压个体中潜在的中风风险因素.
- 升高cSBP和动脉硬性对中风风险的综合影响仍然不完全理解.
研究的目的:
- 为了研究中心缩血压升高 (cSBP) 和带脉冲波速度 (cfPWV) 与发生中风风险之间的关联.
- 为了确定cSBP和cfPWV的联合升高是否会比单独的任何一个因素带来更大的中风风险.
主要方法:
- 一项包括6663名没有先前心血管疾病的参与者的队列研究.
- 使用A-Pulse CASPro设备非侵入性测量cSBP,使用Pulse Pen设备测量cfPWV.
- 发生性中风是主要结果,评估时间为4.4年的中位数随访.
主要成果:
- 与基准组相比,患有高cSBP和cfPWV的患者患中风的风险显著增加 (HR1.78).
- 与参考组相比,高cSBP和cfPWV独立地显示,中风风险在统计上没有显著增加.
- 关于中风风险的升高cSBP和cfPWV之间观察到一个显著的附加相互作用 (RERI 0.55).
结论:
- 在cSBP和cfPWV同时升高的高血压患者面临发生中风的风险要大得多.
- 临床注意和个性化治疗策略是必要的高血压患者的联合升高cSBP和动脉硬.
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