孕产妇压力和胎盘皮质醇调节在怀孕年龄小的新生儿中
J Miranda1,2,3, L Benitez1,4, S Macías-Redondo5
1BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain.
概括
孕产妇的压力与怀孕年龄 (SGA) 相关,影响胎盘基因表达和胎儿皮质醇代谢. 减少母亲压力的干预措施可能有利于胎儿的生长.
科学领域:
- 围产儿医学 围产儿医学
- 发展生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 母亲的压力与胎儿的生长和胎盘基因表达有关,特别是HSD11β2.2.
- 之前的研究没有同时检查与胎儿生长相关的孕产妇压力,胎盘HSD11β2表达/甲基化和胎儿皮质醇代谢物.
研究的目的:
- 评估感知产前母亲压力,胎盘HSD11β2基因表达和甲基化,胎儿皮质醇代谢物和出生体重之间的关联.
主要方法:
- 一个嵌套的病例对照研究,涉及单子怀孕,分类为小到妊娠年龄 (SGA) 或适当到妊娠年龄 (AGA).
- 使用感知压力量表 (PSS) 和国家轨道焦虑库存 (STAI) 评估母亲的压力和焦虑.
- 分析了胎盘HSD11β2RNA表达和DNA甲基化,以及羊水皮质醇代谢物和酶活性.
主要成果:
- 与对照组相比,SGA怀孕的孕妇表现出更高的母亲压力和焦虑得分.
- 胎盘HSD11β2RNA表达在SGA病例中较低,DNA甲基化没有显著差异.
- SGA胎儿的皮质醇代谢发生了变化,包括5α-四基皮质醇的增加和6基皮质醇度的降低.
结论:
- 高度感知到的孕产妇压力与怀孕年龄较小 (SGA) 的怀孕有关.
- 在SGA中观察到失调的胎盘皮质醇代谢.
- 减轻母亲的压力可能是改善胎儿生长结果的有益干预.
关键词:
发展规划是指发展规划.表观遗传学是指表观遗传学.胎儿皮质醇代谢的代谢胎儿的成长 胎儿的成长母亲的焦虑和母亲的焦虑母亲的压力是母亲的压力.胎盘的基因表达.对于怀孕年龄来说小.类固醇轴上的类固醇轴更多相关视频
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