蛋白质组与BMI波动和长期变化的关联:一项长达40年的随访研究
Alvaro Obeso1,2, Gabin Drouard3, Teemu Palviainen3
1Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country, Bilbao, Spain.
Diabetes, obesity & metabolism
|May 9, 2025
概括
长期的体重变化和波动与1000多种血蛋白有关,环境因素在成年后的蛋白质组关联中起着关键作用.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 代谢健康 代谢健康
- 双胞胎研究 双胞胎研究
背景情况:
- 对蛋白质组与长期体重增加和身体质量指数 (BMI) 波动的关联的理解有限.
- 以前的研究主要集中在基于干预的体重变化.
- 需要探索血蛋白与纵向BMI变化之间的关系.
研究的目的:
- 调查长期BMI变化和波动与1000多种血蛋白之间的关联.
- 检查BMI (PRSBMI) 的多基因风险评分的作用及其与蛋白质的相互作用.
- 在单胞胎双胞胎中利用对内分析来控制遗传和环境混因素.
主要方法:
- 在五个时间点 (1975-2014) 中分析了304名芬兰成年双胞胎的BMI数据.
- 使用线性混合效应模型分析的血液样本中的蛋白质组数据.
- 计算BMI轨迹,BMI波动,以及与血蛋白和PRSBMI的关联分析.
主要成果:
- 135种与长期BMI变化相关的蛋白质和17种与BMI波动相关的蛋白质.
- 在双胞胎内对分析后,仍有12个显著的关联 (10与BMI变化,2与波动).
- PRSBMI与BMI变化相关,但没有发现有意义的PRSBMI-蛋白相互作用影响BMI趋势.
结论:
- 血蛋白与长期的BMI变化和波动之间存在显著的关联.
- 环境因素在整个成年期显著影响蛋白质和BMI的关联.
- 没有证据表明PRSBMI-蛋白相互作用调解这个队列中的BMI趋势.
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