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在GCF和牙周炎中MCP-1水平之间的关系:通过元分析和分子相互作用分析进行系统审查

Mario Alberto Alarcón-Sánchez^1,2, Ruth Rodríguez-Montaño^2,3, Sarah Monserrat Lomelí-Martínez⁴

¹Molecular Biology Department, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara, Jalisco, Mexico.

Journal of cellular and molecular medicine

|May 9, 2025

概括

单细胞化学吸引蛋白1 (MCP-1) 在牙周炎患者的牙裂液 (GCF) 中显著升高. 这一发现表明MCP-1是MCP-1.

科学领域:

牙周病学牙周病学
免疫学免疫学免疫学
生物标志物研究生物标志物研究

背景情况:

单细胞化学吸引蛋白1 (MCP-1) 在炎症过程中发挥作用,包括牙周炎.
MCP-1 影响单细胞化学反应,内皮激活和白细胞功能.
了解MCP-1在牙周炎中的作用可能会提供诊断见解.

研究的目的:

系统地审查和元分析MCP-1在慢性牙周炎的牙裂液 (GCF) 中的作用.
在牙周炎患者和健康个体之间比较GCF中的MCP-1水平.

主要方法:

按照PRISMA指南进行系统审查和元分析.
在多个数据库 (PubMed,Scopus,科学网等) 进行的搜索. ) 的情况.
使用JBI工具进行质量评估;用于MCP-1度元分析的随机效应模型.

主要成果:

最初确定了1694篇文章;14篇研究符合纳入标准,其中10篇被纳入定量分析.
总共分析了497名参与者 (298例,199例对照).
分析显示,与健康对照人群相比,慢性牙周炎患者的GCF中MCP-1水平显著更高 (SMD=20.29,p=0.001).

结论:

在GCF中MCP-1水平升高与慢性牙周炎有关.
在临床环境中,GCF MCP-1显示出作为未来牙周炎诊断生物标志物的潜力.

关键词:

生物标志物生物标志物牙裂液牙裂液牙裂液单细胞化疗吸引蛋白质 1 1 牙周病是一种牙周病.牙周炎是指牙周炎的一种疾病.

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