通过构建一个八个成员的环合成dibenzodiazocinediimine的研究
Bing Wang1, Mengyao Mi1, Shu-Jia Li1
1Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
The Journal of organic chemistry
|May 9, 2025
概括
一个新的单步合成产生二[b,f][1,5]二素-6,12(5H,11H) -二胺和类似物. 这种简单的策略有效地从易于获得的前体中产生新的八个环组成的化合物.
科学领域:
- 有机合成 有机合成
- 异环化学 异环化学
- 药用化学 医学化学
背景情况:
- 二子[b,f][1,5]二素-6,12(5H,11H) -二胺衍生物是重要的异环基架.
- 这些化合物的高效合成途径对于进一步的研究和开发至关重要.
研究的目的:
- 建立一个简单和高效的单步策略来合成二[b,f][1,5]亚素-6,12(5H,11H) -二胺及其类型.
- 探索相关的5,12-二二子[b,f][1,4]二素-6,11-二胺衍生物的合成.
- 在类似的条件下,研究烯和各种氨基之间的反应.
主要方法:
- 使用o-aminobenzonitrile或o-phenylenediamine/phthalonitrile衍生物作为起始材料.
- 采用一步循环化策略来构建八个环系统.
- 在优化条件下,在arylnitriles和各种氨基之间进行反应.
主要成果:
- 成功合成了12种化合物,包括9种新的二[b,f][1,5]二素-6,12(5H,11H) -二胺类同类物,产量为62-95%.
- 合成了五种新的5,12-二二[b,f][1,4]亚素-6,11-二胺衍生物,产量为35-52%.
- 在开发条件下证明了基和各种氨基之间的有效反应.
结论:
- 既定的一步策略提供了一个简单而有效的途径,dibenzo[b,f][1,5]diazocine-6,12(5H,11H) -diimine衍生物及其类似物.
- 反应条件是多功能性的,允许合成相关的二素结构和甲胺合产物.
- 已经提出了一种可能的反应机制,其中作为启动循环的基础.
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