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在复发性和耐火性多发性髓瘤中,MAMDC2-AS1诱导cuproptosis

Yifei Chen¹, Jun Liu¹, Ying Zhu¹

¹Department of Hematology, Jiangdu People's Hospital, Yangzhou City, China.

Cancer reports (Hoboken, N.J.)

|May 9, 2025

概括

研究人员确定MAMDC2-AS1是复发性和耐火性多发性骨髓瘤 (RRMM) 中的关键长非编码RNA. 这种生物标志物预测患者的存活率,并可能指导这种侵袭性血液癌症的新治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

多发性骨髓瘤 (MM) 是一种血细胞恶性瘤,在复发性/耐药性 (RRMM) 病例中预后不佳.
对于RRMM的潜在机制仍然不完全理解,需要新的预后标志物.

研究的目的:

通过使用RNA-Seq数据,研究RRMM中的分子机制并确定RRMM中的预后生物标志物.
评估已识别的生物标志物在预测患者生存中的潜力.

主要方法:

来自557名RRMM患者的骨髓RNA-Seq数据的分析 (GEO数据库GSE24080).
使用LASSO Cox回归识别差异表达基因和长非编码RNA (lncRNAs).
使用定量PCR (qPCR) 和57名MM患者的生存分析验证发现.

主要成果:

在RRMM患者中观察到与cuproptosis相关的基因显著上调.
一些 lncRNAs 被确定为影响铜诱导的细胞死亡和患者预后.
在RRMM中,MAMDC2-AS1被确定为总生存 (OS) 的重要独立预测因子 (p < 0.01).
通过lncRNAs分层的高风险组显示明显更差的OS (p < 0.001).

结论:

MAMDC2-AS1是RRMM病变发生过程中至关重要的lncRNA,并作为一种强大的预后生物标志物.
包括博尔特佐米布,博苏替尼,克里佐替尼和DMOG在内的向疗法在高级RRMM中表现有前途.

关键词:

在MAMDC2-AS1之间.这是一个RRMM.这就是cuproptosis.在 lncRNA 中,预后预后预后

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