在乳头甲状腺癌监测期间的体型增加:证据综合和剂量反应元分析
Mohamed Badie Ahmed1,2, Emad Naem3, Harman Saman4,5
1Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Cancer reports (Hoboken, N.J.)
|May 9, 2025
概括
在积极监测期间,乳头甲状腺癌 (PTC) 的大小进展缓慢,每年增加不到1%. 大多数监测的PTC病变在20年内不会达到3mm的大小值.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 癌症监测 癌症监测
背景情况:
- 分化甲状腺癌,主要是乳头甲状腺癌 (PTC),是常见的.
- 许多PTC病变是无症状的,并偶然发现.
- 积极监测是低风险PTC的管理策略.
研究的目的:
- 在积极监测期间评估乳头甲状腺癌 (PTC) 瘤大小随时间的进展.
- 为了确定在监视期间PTC进展率达到或超过3mm的速度.
主要方法:
- 使用了剂量反应元分析和元回归.
- 在PubMed/MEDLINE和EMBASE进行文献搜索,截至2024年8月.
- 时间被用作"剂量"来评估累积进展的百分比.
主要成果:
- 分析了21项涉及14648名参与者的研究.
- 2年后的进展率为1%,在20年后线性上升至12%.
- 进展率大约为每年<1%.
结论:
- 乳头甲状腺癌 (PTC) 尺寸进展超过3mm,随着时间的推移线性增加.
- 进展到3mm值发生在少数患者在20年内.
- 积极监测是管理小PTC病变的可行策略.
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