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长期单边感应神经神经听力损失中大脑和小脑结构的形态测量评估

Gözde Orhan Kubat¹, Özkan Özen², Emre Çolak¹

¹Alanya Alaaddin Keykubat University School of Medicine, Department of Otolaryngology, Alanya, Antalya, Turkey.

Brazilian journal of otorhinolaryngology

|May 9, 2025

概括

长期单边感应神经听力损失 (USNHL) 可能导致大脑结构变化. 具体来说,观察到前额骨和小脑的灰质体积增加,以及更厚的上状.

科学领域:

神经成像是一种神经成像.
听觉神经科学听觉神经科学
神经可塑性神经可塑性

背景情况:

结构性大脑变化与听力损失有关.
长期单边感应神经听力损失 (USNHL) 对大脑形态的影响尚不清楚.

研究的目的:

调查长期USNHL的成年人的大脑和小脑形态变化.
为了在USNHL患者和健康对照中比较受影响和正常听力侧的脑结构.

主要方法:

使用了磁共振成像 (MRI) 和基于voxel的形态测量 (VBM).
12名长期USNHL成年人和12名健康对照参与了这项研究.
评估了大脑和小脑结构的形态变化.

主要成果:

与对照组相比,USNHL患者表现出额头骨灰质体积增加 (p=0.024).
在USNHL患者中观察到上时回路厚度 (p=0.041) 和小脑IX灰质体积 (p=0.025) 的增加.
在USNHL患者的完整和正常听力侧之间没有发现显著差异.

结论:

长期的USNHL可能会在参与听觉处理和运动控制的大脑区域中诱导神经适应性形态变化.
需要对更大的队列进行进一步的研究,以了解诊断和治疗的临床影响.

关键词:

听觉皮层中的听觉皮层.大脑形态测量灰色物质是一种灰色物质.听力损失听力损失单边权益是一种单边权益.

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