在接受物质使用障碍治疗的住院患者中唾液皮质醇轨迹:一个前性的重复措施研究
Eli Otterholt1, Petter Laake2, Stål Bjørkly1
1Faculty of Health and Social Science, Molde University College, Molde, Norway.
Psychoneuroendocrinology
|May 9, 2025
概括
药物使用障碍 (SUD) 患者的唾液皮质醇水平在住院治疗的前四周下降,然后稳定. 阿片类药物使用障碍患者的皮质醇水平低于兴奋剂使用障碍患者.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 研究表明,在有物质使用障碍 (SUD) 的住院患者中,皮质醇水平和治疗结果之间存在联系.
- 关于在住院SUD治疗期间的皮质醇水平模式的数据有限.
研究的目的:
- 在8周的住院SUD治疗期间检查唾液皮质醇水平的变化.
- 确定主要SUD诊断是否影响皮质醇水平轨迹.
主要方法:
- 使用前性,重复测量设计,对173名被诊断患有各种SUD的患者进行了测试.
- 唾液皮质醇是在治疗的第2,4,6周和第8周收集的.
- 线性混合模型分析 (LMMs) 评估了皮质醇度 (AUCg) 以及它们与诊断和治疗因素的关联.
主要成果:
- 皮质醇水平从第2周到第4周显著下降 (p < 0.001),然后稳定.
- 与兴奋剂使用障碍患者相比,患有阿片类药物使用障碍 (OUD) 的患者表现出较低的皮质醇轨迹 (p < 0.001).
- 长期治疗单位的患者表现出比短期治疗单位的患者更高的皮质醇轨迹 (p = 0.048).
结论:
- 在住院SUD治疗的最初4周内,皮质醇水平下降,随后稳定.
- 与OUD患者相比,刺激剂使用障碍患者的皮质醇水平随着时间的推移而更高.
- 对于个性化治疗方法,建议对多种物质使用的临床影响和缓解作用进行进一步的研究.
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