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Updated: May 12, 2025

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肠道失调和手术并发症之间的双向相互作用:一个系统的审查
Lindsey Nichols1, Omar El-Kholy2, Ahmed Adham R Elsayed3
1College of Medicine, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
American journal of surgery
|May 9, 2025
概括
手术会破坏肠道微生物群,导致失能并增加并发症风险. 益生菌可以通过恢复手术后的细菌平衡来帮助减轻这些不良影响.
科学领域:
- 微生物学 微生物学
- 手术科学 手术科学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物组在生理功能和手术恢复中起着至关重要的作用.
- 手术干预可以显著改变肠道微生物群,可能增加并发症的风险.
研究的目的:
- 为了研究手术程序和肠道失生症之间的复杂的双向关系.
- 了解手术如何影响肠道微生物组,反之亦然.
主要方法:
- 在2024年12月22日,在主要数据库 (Cochrane Library,PubMed,VHL,WOS) 进行了系统的文献搜索.
- 包括的研究经过严格评估,使用STROBE和CONSORT指南对偏差风险进行了严格评估.
主要成果:
- 分析了30项涉及2500多名参与者的研究,揭示了肠道失调和手术并发症之间的相关性.
- 患有并发症的患者表现出肠道细菌的不平衡,其特点是有害细菌增加,有益细菌减少.
- 一些研究表明,益生菌干预可能会降低术后并发症的发生率.
结论:
- 肠道失调与术后并发症密切相关,通过双向相互作用.
- 在经历手术并发症的患者中观察到肠道微生物组合的改变,有益细菌减少,致病性细菌增加.
- 早期检测肠道失生症和战略性使用益生菌可能为预测和减轻术后并发症提供潜力.
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