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Updated: May 16, 2025

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在 HepG2 细胞中,SETDB1 衰退通过 DRP1 酸化介导的线粒体功能障碍促进对索拉尼的耐药性

Mingjian Fan1, Jiahang Wu1, Yunjiao Wu2

  • 1KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 511436, China.

Biochemical and biophysical research communications
|May 9, 2025
PubMed
概括

肝脏SETDB1表达通过预防线粒体功能障碍和过度DRP1酸化,提高了肝细胞癌 (HCC) 中索拉芬尼的疗效. 在HCC患者中,SETDB1可作为索拉芬尼治疗的预测生物标志物.

关键词:
DRP1 DRP1 的使用方法肝细胞癌是肝细胞癌.线粒体中的线粒体.在SETDB1中,我们可以使用SETDB1.索拉费尼布 (Sorafenib) 是一种

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