对于运动障碍的可解释机器学习 - 震和肌肉的分类
Elina L van den Brandhof1, Inge Tuitert2, A M Madelein van der Stouwe3
1Expertise Center Movement Disorders Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Bernoulli Institute for Mathematics, Computer Science and Artificial Intelligence, University of Groningen, Groningen, the Netherlands.
机器学习使用加速度计数据准确地区分了基本震 (ET) 和皮质肌 (CM). 这种方法分析运动模式,为改善这些疾病的诊断准确性提供了一个潜在的工具.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 机器学习 机器学习
背景情况:
- 基本震 (ET) 和皮质肌 (CM) 具有共同的症状,使得临床区分具有挑战性.
- 观测者之间和观测者内部的高变异性需要改进ET和CM的诊断工具.
研究的目的:
- 开发一种机器学习 (ML) 模型,利用加速度计数据来区分ET和CM.
- 为临床医生提供一个客观的工具,以帮助诊断ET与CM.
主要方法:
- 采集了19名ET和19名CM患者的上肢运动数据,使用8个加速度计传感器在21个任务中进行了21次任务.
- 应用可解释的ML (通用矩阵学习向量的定量化 - GMLVQ) 来进行加速计记录的功率频谱分析以进行分类.
- GMLVQ确定了相关的频率模式,有助于表型分类.
主要成果:
- 在静态和动态任务中实现了优异的分类性能 (AUROC接近1.0).
- GMLVQ确定了关键频段 (5-7 Hz,3-4 Hz,9-10 Hz),这些频段对于区分ET和CM至关重要.
- 这些频率与文献中已知的震峰和光谱特征保持一致.
结论:
- 证明了使用加速度计功率光谱的GMLVQ分析来区分ET和CM的概念证明.
- 开发的ML方法显示,它有可能提高治疗ET和CM的临床医生的诊断准确性.
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