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相关概念视频

Kidney Structure01:45

Kidney Structure

67.0K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
67.0K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

546
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
546
Nephrons01:10

Nephrons

1.7K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
1.7K
Filtration and Urine Formation01:32

Filtration and Urine Formation

47.8K
The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
47.8K

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相关实验视频

Updated: May 14, 2025

Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

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在人类脏器官中整合收集系统,通过距离脏与尿道芽的融合.

Min Shi1, Brittney Crouse1, Nambirajan Sundaram2

  • 1Division of Nephrology and Hypertension, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Cell stem cell
|May 9, 2025
PubMed
概括

研究人员开发了一种新方法,通过结合特定细胞类型来制造具有连接的收集管 (CD) 的人类器官. 这一突破使得功能性脏组织的工程具有完整的脏结构.

关键词:
组合物质组合物质组合物收集系统的收集系统.脏中的有机物.的再生 的再生甲基尼弗里克介质基因人类的新生是nephrogenesis.尼弗朗融合是什么意思尼弗朗细分 尼弗朗细分泌尿器的芽是什么意思

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Dissection and Culture of Mouse Embryonic Kidney
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Dissection and Culture of Mouse Embryonic Kidney

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Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
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Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

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相关实验视频

Last Updated: May 14, 2025

Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

4.5K
Dissection and Culture of Mouse Embryonic Kidney
08:30

Dissection and Culture of Mouse Embryonic Kidney

Published on: May 17, 2017

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Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
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科学领域:

  • 发育生物学是发展生物学.
  • 干细胞研究的研究.
  • 再生医学是一种再生医学.

背景情况:

  • 脏对于平衡至关重要,依靠连接到收集管道 (CDs) 的脏来排泄废物.
  • 目前的人类多能干细胞衍生器官缺乏CD,导致盲目的管道和有限的功能.

研究的目的:

  • 开发一种用于产生具有功能性收集管网的器官的方法.
  • 为了研究脏发育过程中脏收集管融合的机制.

主要方法:

  • 组装诱导的质介质与尿道芽的祖先.
  • 利用一个发育灵感的人类多能干细胞分化系统.
  • 通过时间通路操纵调节近端-远端脏模式.

主要成果:

  • 成功生成了具有通过与远端管道融合而集成的收集管道网络的脏器官.
  • 证明了脏收集管融合是一个由脏模式调节的刻板印象过程.
  • 建立了一个研究-尿道芽融合机制的平台.

结论:

  • 本研究提出了一种新的策略,用于设计具有完整脏结构的脏器官,包括收集系统.
  • 这些发现为推进功能性脏组织的新生代提供了框架.
  • 开发的系统有助于对脏发育和融合原理的研究.