超可扩展的双交叉连接全纤维素海绵:在严重出血中为止血的物理和化学解决方案
Xinsen Lin1, Siqi Zhang1, Weijie Jiang2
1Department of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
概括
一种全纤维素海绵迅速扩张,通过施加物理压力和化学静血来阻止严重的出血. 这种可生物降解的血液静止材料为管理无法控制的出血提供了一种绿色替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 化学工程是化学工程的重要组成部分.
- 医疗器械 医疗器械
背景情况:
- 失控的出血,特别是来自深层伤口的出血,代表了危及生命的危急状况.
- 现有的静血材料往往在有效管理严重出血方面存在局限性.
研究的目的:
- 开发一种可注射,超级可扩展的全纤维素基海绵,用于有效控制出血.
- 研究新型海绵的双重静血机制 (物理扩张和化学结合).
- 评估开发材料的静血效率和生物降解性.
主要方法:
- 通过使用双孔生成策略的针叶纸纤维 (Pulp) 和碳甲基纤维素 (CMC) 进行双重交叉连接,制造全纤维素海绵 (Pulp-CMC).
- 在模拟出血条件下评估海绵膨胀比率.
- 在猪大腿动脉出血和刺伤模型中对血静效能的评估,与布相比.
- 在土壤中确定生物降解性.
主要成果:
- 纸-CMC海绵表现出超级可扩展性质,达到约3900%的高度扩张比,这是血液静止材料中报告的最高水平.
- 这种海绵表现出双重的静血作用:由膨胀引起的快速物理压力和通过结合Fe3+离子的碳素基团的化学静血作用.
- 观察到出血量显著减少:81%的猪大腿动脉出血和86%的刺伤模型与布相比.
- 当被埋在土壤中时,海绵在30天内完全可生物降解.
结论:
- 开发的可注射和超级可扩展全纤维素海绵提供了高效的静血材料.
- 它的双重物理和化学静血机制,加上快速膨胀和生物降解性,使其成为临床应用中管理严重出血的有希望的绿色替代品.
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