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Updated: May 12, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

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洞察由U-U和T-T不匹配在RNA和DNA复合体中的U-U和T-T不匹配形成的符合性合奏,来自基于结构的调查,NMR和分子动力学模拟

Ainan Geng1, Rohit Roy2, Stephanie Gu1

  • 1Department of Biochemistry, Duke University School of Medicine, Durham, NC 27701, USA.

Journal of molecular biology
|May 9, 2025
PubMed
概括

核酸中的 uracil-uracil 和 thymine-thymine 不匹配在纳米秒时间尺度上的摇摆形状之间动态互转. 这些无处不在的次微秒运动影响了核酸的可塑性和功能.

关键词:
核酸动态学 核酸动态学在RNA组合中,RNA组合组合.T-T不匹配的情况这是一个U-U不匹配.自由能源的景观.

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