童年不良经历与长期血压变化之间的关联:来自聚合分析的见解
Guangjun Zheng1, Zhenger Fang1, Biying Zhou1
1Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 West Huangpu Avenue, Guangzhou, 510362, China.
Journal of affective disorders
|May 9, 2025
概括
童年不良经历 (ACE) 与长期血压变化 (BPV) 的增加有关. 这种关联在高血压患者中更为明显,突显了早期干预的必要性.
科学领域:
- 公共卫生 公共卫生
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 儿童不良经历 (ACE) 与长期血压变化 (BPV) 之间的联系以前没有被研究过.
- 了解这种关联对于制定有针对性的公共卫生干预措施至关重要.
研究的目的:
- 为了研究ACE和BPV之间的纵向关联.
- 探索高血压是否会改变ACE和BPV之间的关系.
主要方法:
- 综合分析了来自健康与退休研究 (HRS),英国老龄化纵向研究 (ELSA) 和中国健康与退休纵向研究 (CHARLS) 的数据.
- 通过从问卷中得出的总分来量化ACE.
- 血压变化被评估使用心压和心压血压的标准偏差 (SD).
- 使用线性回归和随机效应元分析来确定关联和聚合效应.
主要成果:
- 童年不良经历 (ACE) 与较高的缩血压变化有显著的相关性 (聚合β:0.131).
- 还观察到一种趋势,即扩张性血压变化更高 (聚合β:0.092).
- 在患有高血压的参与者中,ACE和BPV之间的关联更为明显,特别是对于缩BP (聚合β:0.189).
结论:
- 童年不良经历 (ACE) 与长期血压变化 (BPV) 的增加有显著关联.
- 高血压状态在修改这种关系方面发挥着重要作用.
- 建议对ACE患者,特别是高血压患者进行早期干预和支持.
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