脱水仁可以改善糖尿病病症中脏结构受损的情况
Nivedita Singh1, Anuradha Kesharwani1, Harsha Sankar S H2
1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research Hajipur-844102, Bihar, India.
概括
高脂肪饮食通过破坏运输和增加氧化应激会损害糖尿病小鼠的功能. 脱激素 (DH) 治疗有助于通过改善这些过程来恢复脏健康.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢学 代谢学 代谢学
- 分子生物学分子生物学
背景情况:
- 糖尿病是慢性病的主要危险因素,但机制尚不清楚.
- 高脂肪饮食 (HFD) 诱导的糖尿病导致功能障碍和损伤.
- 了解糖尿病中的分子变化对于开发治疗方法至关重要.
研究的目的:
- 通过转录和蛋白质组分析研究HFD对小鼠脏组织的长期影响.
- 评估脱水 (DH) 在改善HFD诱导的糖尿病病方面的潜力.
- 阐明导致功能障碍的分子机制和DH的治疗效果.
主要方法:
- 从高脂肪饮食 (HFD) 或正常饮食 (NCD) 食小鼠的脏组织的转录和蛋白质组分析,有或没有脱甘 (DH) 治疗.
- 在小鼠中使用HFD和链毒素 (STZ) 诱导糖尿病.
- 通过生物化学标记物 (白蛋白尿,蛋白尿) 和蛋白质和基因表达的分子分析来评估功能.
主要成果:
- 由HFD诱导的糖尿病导致严重的功能障碍,其特征是白蛋白尿,蛋白尿和改变的血清标志物.
- 脏损伤包括膜过系统的缺陷,运输和代谢蛋白的降低调节,以及脂质代谢受损.
- 食HFD增加了氧化应激,诱导了线粒体功能障碍,激活了亡 (BAX通路),并触发了表观遗传变化 (HDAC1激活).
- 脱激素 (DH) 治疗积极调节了运输系统,线粒体功能,脂质代谢,DNA损伤,表观遗传变化和氧化应激,改善了功能.
结论:
- 长期HFD养导致脏的复杂分子变化,包括运输受损,脂质代谢,氧化应激增加,线粒体功能障碍和表观遗传变化.
- 脱甘 (DH) 通过逆转这些有害的分子变化,显示出在缓解HFD诱导的糖尿病病方面的显著潜力.
- DH代表了治疗糖尿病病的有前途的治疗药物,需要进一步研究.
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