设定一天的基调:皮质醇唤醒反应主动调节前边缘电路来处理情绪
Changming Chen1, Bingsen Xiong2, Wenlong Tan2
1School of Education, Chongqing Normal University, Chongqing, 401331, China.
NeuroImage
|May 9, 2025
概括
皮质醇唤醒反应 (CAR) 准备大脑应对压力. 这项研究表明,CAR主动影响成年男性情绪处理的前边边缘大脑连接.
科学领域:
- 神经科学是一个神经科学.
- 心理生理学 心理生理学
- 内分泌学 在内分泌学.
背景情况:
- 皮质醇唤醒反应 (CAR) 与精神疾病有关,并可能为大脑准备应对压力.
- 关于CAR对情绪处理的积极影响的基础的神经生物学机制尚不清楚.
研究的目的:
- 调查CAR在调节情绪处理的前边边缘功能组织中的因果作用.
- 为了检查抑制CAR如何影响情绪化面部匹配任务期间的大脑活动.
主要方法:
- 这是一项双盲,安慰剂控制的研究,涉及36名男性成年人接受德甲 (DXM) 抑制CAR,和31名对照.
- 功能磁共振成像 (fMRI) 和心理生理相互作用 (PPI) 分析在情感面部匹配任务 (EFMT) 中使用.
主要成果:
- 与安慰剂组相比,DXM组对EFMT的情绪状况的准确性较低.
- 在DXM组中,按任务组的相互作用显示了杏仁体和前额/部区域之间功能连接的改变.
- 具体来说,在DXM组观察到,在情绪处理过程中,右杏仁体-左DLPFC连接更强,在对照条件下,左杏仁体-右MTG连接更弱.
结论:
- 在成年男性中,CAR主动调节前边缘功能组织以处理情绪.
- 研究结果支持CAR与其对情绪处理的积极影响之间存在因果关系.
- 汽车可以为日常大脑准备调节对情绪刺激的反应设置增强基调.
相关概念视频
Hypothalamic-Pituitary Axis
58.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
58.3K
Physiology of Emotion
421
The physiology of emotions is a multifaceted process involving the autonomic nervous system, brain structures, hormones, and neurotransmitters. This intricate interplay dictates how emotions manifest in the body and influence behavior.
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
421
Functional Brain Systems: Limbic System
1.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep...
1.9K
Physiological Foundation of Stress
24
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
24
Hormones of the Adrenal Glands
2.0K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.0K
Role of Cerebellum and Prefrontal Cortex in Memory
214
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
214


