获得了对维穆拉芬尼的耐药性通过抑制STAT3激活来抑制甲状腺癌干细胞自我更新

Yuqing Zhao1, Yurong Lu1, Wei Li2

  • 1Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, PR China.

PubMed
概括

适应Vemurafenib (PLX4032) 的甲状腺癌细胞显示自我更新能力降低. 这种药物耐药性与STAT3激活受损和关键干性基因的表达降低有关.

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