最近的免疫细胞在外周神经系统的性别差异在持续疼痛状态的历史
Madelene Faye S Ho1, Olivia Farkas1, Andre Vilela Faria1
1Neuroscience and Mental Health Institute, University of Alberta, Canada.
Brain, behavior, and immunity
|May 9, 2025
概括
生物性别显著影响疼痛和免疫反应. 这篇评论详细介绍了巨细胞,T细胞和B细胞如何导致慢性疼痛,强调了针对性治疗的性别特异性作用.
科学领域:
- 神经免疫学 神经免疫学
- 免疫学 免疫学 免疫学
- 疼痛研究 疼痛研究
背景情况:
- 生物性影响免疫系统机制,使女性易患自身免疫性疾病和慢性疼痛.
- 从历史上看,研究中女性受试者占比不足,尽管性别在自身免疫性疾病和疼痛中至关重要.
- 动物研究揭示了性别特异的疼痛机制:男性疼痛是微质驱动的,而女性疼痛是T细胞驱动的.
研究的目的:
- 在神经病变和炎症性疼痛期间审查周围神经系统中巨细胞,T细胞和B细胞的最新作用.
- 讨论这些免疫细胞类型的性别相似性和差异.
- 探索基于免疫的治疗方法,治疗性偏差的自身免疫性疾病中的慢性疼痛.
主要方法:
- 在神经免疫学和疼痛研究中对现有文献进行小型审查.
- 在神经病和炎症性疼痛模型中,分析了专注于免疫细胞的研究.
- 综合了关于免疫细胞性别特异性作用的发现.
主要成果:
- 免疫细胞,包括巨细胞,T细胞和B细胞,在外周神经系统中在持续性疼痛中发挥重要作用.
- 免疫细胞参与中的性别差异至关重要,并且比最初理解的更复杂.
- 了解这些性别特定的角色是开发有针对性的疼痛治疗的关键.
结论:
- 周围神经系统中的免疫细胞群在慢性疼痛状态中至关重要.
- 性别特定的免疫反应有助于不同的疼痛易感性和机制.
- 针对性别特定的免疫路径为新型慢性疼痛治疗提供了一个有希望的途径.
相关概念视频
01:44Nociception
28.4K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.4K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
1.8K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.8K