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Updated: May 12, 2025

Cryo-Structured Illumination Microscopic Data Collection from Cryogenically Preserved Cells
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在血液学研究中的冷SEM.

Irina Davidovich1, Carina Levin2,3, Yeshayahu Talmon1

  • 1Department of Chemical Engineering and the Russell Berrie Nanotechnology Institute (RBNI), Technion-Israel Institute of Technology, Haifa, Israel.

Journal of microscopy
|May 9, 2025
PubMed
概括

低温扫描电子显微镜 (cryo-SEM) 提供了水合细胞的高分辨率成像. 这种使用高压结的技术,揭示了复杂的细胞细节,用于先进的生物和血液学研究.

关键词:
血液细胞 细胞 血细胞低温电子显微镜的低温电子显微镜.化SEM-SEM可以使用.血液学 血液学高压冷方式的高压冷.在Rouleaux的形成.玻璃化 玻璃化 玻璃化

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Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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