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Updated: May 16, 2025

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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血膜蛋白质的BiDAC-依赖性降解由内解体系统进行

Sammy Villa1, Qumber Jafri1, Julia R Lazzari-Dean1

  • 1Calico Life Sciences LLC, South San Francisco, CA, USA.

Nature communications
|May 9, 2025
PubMed
概括

双功能降解激活化合物 (BiDACs) 促进蛋白质清除. 这项研究揭示了BiDACs可以向像EGFR和Her2这样的膜蛋白进行溶酶体降解,涉及蛋白质体和PQLC2.

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