孕产妇的肠道微生物群会影响母胎界面的免疫激活,从而影响怀孕的结果
Silvia Giugliano1,2, Andrea Gatti3,4, Martina Rusin5,3
1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, 20072, Italy. silvia.giugliano@hunimed.eu.
Nature communications
|May 9, 2025
概括
怀孕期间母亲的肠道失调会导致胎儿并发症和类似于子宫前的症状. 补充葡萄糖可以恢复免疫功能并减少胎儿的再吸收,突出显示肠道微生物群在怀孕健康中的作用.
科学领域:
- 生殖免疫学 生殖免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 微生物组研究 微生物组研究
背景情况:
- 孕前是导致妊娠并发症的主要原因,与免疫问题和代谢障碍有关.
- 孕产妇的肠道失调越来越被认为是导致不良妊娠结果的因素.
研究的目的:
- 调查母体肠道失生症对胎盘发育和怀孕结果的影响.
- 探索胎盘碳水化合物代谢和免疫细胞功能在孕前发展中的作用.
主要方法:
- 利用小鼠模型 (C57BL/6J大) 在怀孕期间诱导肠道失调.
- 评估胎儿再吸收,胎盘发育,血管化,缺氧,内分泌网膜 (ER) 压力和子宫自然杀手 (NK) 细胞功能.
- 研究葡萄糖补充剂对胎盘NK细胞功能和胎儿结局的影响.
主要成果:
- 肠道功能失调导致胎儿吸收增加,胎盘发育受损,血管化发生改变.
- 失生症引起的缺氧,ER压力,减少NK细胞数量,以及由于胎盘碳水化合物代谢发生变化而导致NK细胞IFN-γ分泌受损.
- 葡萄糖补充恢复了NK细胞的功能,并降低了胎儿的再吸收,这表明可逆的,依赖于糖分分解速率的损伤.
结论:
- 母亲的肠道微生物群通过碳水化合物代谢对胎盘免疫力和怀孕结果产生重大影响.
- 准肠道微生物群和代谢途径是预防产前的潜在策略.
- 研究结果表明,新型的代谢生物标志物可用于产前风险评估.
更多相关视频
07:13Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
Published on: March 25, 2016
18.2K
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.5K
相关概念视频
Anatomy of the Intestines
70.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.6K
Development of Immunocompetence
242
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
242
Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
Irritable Bowel Syndrome I: Introduction
207
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
207
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
