通过女性介导的精子选择性激活可能会重塑人类主要的基因相容性综合体为基础的伴侣选择决策
Annalaura Jokiniemi1, Tanja Turunen1, Mikko Kohonen1
1Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland.
Heredity
|May 9, 2025
概括
人类更喜欢MHC类似的伴侣的气味,但精子功能最好与MHC不同的伴侣. 这表明伴侣选择中存在相反的力量,伴侣选择防止不兼容伴侣受精.
科学领域:
- 人类生殖生物学 人类生殖生物学
- 免疫遗传学 免疫遗传学
- 行为生态学 行为生态学
背景情况:
- 主体组织相容性复合体 (MHC) 基因在个体和雌性体水平上影响伴侣选择.
- 这些不同的伴侣选择情节之间的相互作用及其对MHC基因选择的累积影响尚未完全理解.
研究的目的:
- 研究人类在个体 (气味偏好) 和雌性体 (精子性能) 水平上与MHC相关的伴侣选择之间的相互作用.
- 确定MHC相似性/不相似性如何影响女性的气味偏好和随后的精子功能.
主要方法:
- 进行了一项涉及10名女性和11名男性的全因子实验.
- 女人对男性身体气味的吸引力和强度进行了排名.
- 在110个男性和女性组合中,在女性毛囊液的存在下评估了精子的性能.
- 分析包括总的MHC相似性 (经典和非经典基因).
主要成果:
- 雌性更喜欢与MHC相似的雄性的身体气味.
- 精子运动性通过MHC不同的男性和女性组合得到增强.
- 仅考虑经典的MHC基因时,没有发现任何关联.
- 女性的气味偏好与卵泡液治疗后的精子运动率有负相关性.
结论:
- 个人和伴侣选择机制可以在对立中运作.
- 根据气味来看,最有吸引力的雄性可能不是最适合生殖的最佳伴侣.
- 配体介导的伴侣选择可能在防止基因不相容的伴侣受精方面发挥着至关重要的作用.
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