相关实验视频

Updated: May 12, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

甲状腺球蛋白变化对差异化甲状腺癌与生化不完全反应的临床结果的影响

Xiaohui Li¹, Tian Tian¹, Kexin Shi¹

¹Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China.

|May 9, 2025

概括

对差异化甲状腺癌 (DTC) 患者具有生化不完整反应 (BIR) 的监测甲状腺蛋白 (Tg) 水平至关重要. 显著增加Tg水平可以预测结构性复发,有助于个性化患者护理.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
核医学就是核医学.

背景情况:

在放射性治疗 (RAIT) 后,分化甲状腺癌 (DTC) 患者的生化不完全反应 (BIR) 面临结构性复发的风险.
个性化患者管理需要准确预测这种队列中的结构性复发.

研究的目的:

为了确定DTC患者在初始RAIT后出现BIR的结构性复发的预测因素.
分析甲状腺蛋白 (Tg) 变化水平在预测结构性复发中的有用性.

主要方法:

对4263名DTC患者的回顾性分析,这些患者接受了甲状腺切除术和初始RAIT治疗.
纳入标准:抑制的甲状腺蛋白 (Sup-Tg) >1 ng/mL或刺激的Tg (Sti-Tg) >10 ng/mL,阴性抗Tg抗体,没有结构性疾病.
对临床病理参数和纵向Tg变化 (ΔSup-Tg%) 的分析,以预测结构性复发.

主要成果:

分析了161名BIR患者;8.7%进展到结构性疾病.
ΔSup-Tg% ≥17.08%显示高特异性 (84.4%) 预测结构性复发.
甲状腺外延伸,第三阶段和 ΔSup-Tg% 是结构性复发的独立预测因素 (ORs 从 4.568 到 18.781).

结论:

纵向监测甲状腺蛋白 (Tg) 水平对于管理BIR的DTC患者至关重要.
Tg变化水平 (ΔSup-Tg%) 作为结构性复发的有价值预测指标,使更个性化的治疗策略成为可能.

关键词:

生物化学不完整的反应有差异化的甲状腺癌.复发. 复发. 这是一个复发.结构性疾病是一种结构性疾病.甲状腺球蛋白是一种甲状腺蛋白.

更多相关视频

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...