早期青春期的早期生活因素基于韩国全国数据
Myeongseob Lee1, Junghyun Kim2, Haedong Kim3
1Department of Pediatrics, Severance Children's Hospital, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.
Scientific reports
|May 9, 2025
概括
中央早期青春期 (CPP) 风险与儿童出生体重低和身体质量指数较高有关. 母乳养显示出一种保护作用,特别是在女孩身上,防止发展CPP.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 过早的青春期涉及早期的性成熟,在女孩8岁和男孩9岁之前.
- 中部早熟性青春期 (CPP) 源于下丘脑-垂体-腺轴的早期激活,但触发因素尚未完全理解.
- 识别CPP的风险因素对于早期干预和了解发育途径至关重要.
研究的目的:
- 调查影响发展中心早期青春期 (CPP) 风险的变量.
- 分析出生体重,体重指数,母乳养和CPP发育之间的关联.
- 评估儿童早期青春期开始的潜在保护因素.
主要方法:
- 使用韩国国家医疗保险服务数据的回顾性队列研究.
- 包括43,952名被诊断为CPP的儿童和854,749名对照.
- 分析出生体重,体重指数 (BMI) 和与CPP诊断相关的母乳养状况.
主要成果:
- 与对照组相比,患有CPP的儿童的出生体重较低 (男孩: -0.09公斤,女孩: -0.06公斤).
- 低出生体重 (男孩的OR为1.71,女孩的OR为1.30) 和超重/肥胖 (OR为1.14至1.60) 显著增加了CPP风险.
- 母乳养在女孩中显示出对CPP的保护作用 (OR 0.95).
结论:
- 低出生体重和高BMI是中部早期青春期 (CPP) 的重要危险因素.
- 哺乳可能有保护性益处,防止CPP的发展,特别是在女孩身上.
- 这些发现凸显了监测生长参数的重要性,并在CPP风险评估中考虑早期生活因素.
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