六个人类指标的预测值,用于阻塞性睡眠呼吸暂停喘和COPD的患病率和死亡率,使用NHANES数据
Jingdi Hu1, Songwen Tang2, Qijiang Zhu1
1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Scientific reports
|May 9, 2025
概括
这项研究比较了六种肥胖指标的呼吸系统疾病. 像ABSI这样的新型指标预测了阻塞性睡眠呼吸暂停的死亡率,而传统的措施显示了OSA和COPD生存的"肥胖悖论".
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 人类测量学 人类测量学.
背景情况:
- 肥胖是呼吸系统疾病的危险因素,如阻塞性睡眠呼吸暂停 (OSA),喘和慢性阻塞性肺病 (COPD).
- 像身体质量指数 (BMI) 这样的传统措施在反映身体脂肪分布方面存在局限性.
- 新的人类指标提供了评估肥胖及其健康影响的替代方法.
研究的目的:
- 为了比较六个人体测量指标 (BMI,腰围 (WC),腰与身高的比率 (WHtR),身体圆度指数 (BRI),身体形状指数 (ABSI) 和体重调整的腰指数 (WWI)) 与呼吸系统疾病的流行率和死亡率相关.
- 调查这些措施与美国人口中OSA,喘和COPD的患病率之间的关联.
- 评估人类测量方法对这些呼吸系统疾病患者死亡率的预测性能.
主要方法:
- 来自四个国家健康和营养检查调查 (NHANES) 周期的数据分析.
- 多变量后勤回归用于评估人体测量和疾病流行率之间的横截面关联.
- 考克斯的比例危险模型和时间依赖的ROC曲线用于分析死亡率关联和预测性能.
主要成果:
- BMI,WC,WWI,BRI,ABSI和WHtR与OSA和COPD患病率有积极的关联.
- BMI,WC,BRI和WHtR与喘患病率有积极关联;ABSI和第一次世界大战显示出负面关联.
- 较高的WC和BMI与在OSA和COPD (肥胖悖论) 中更好的生存率相关.
- 增加的WWI和ABSI与OSA患者的死亡率增加有关;ABSI显著预测了OSA死亡率 (AUC> 0.74).
结论:
- 新的人类指标 (WWI,BRI,ABSI,WHtR) 与OSA和COPD的患病率相关,类似于传统的措施.
- 作为OSA的死亡率预测指标,ABSI显示出前景,为中心肥胖的影响提供了洞察力.
- 传统的措施可能无法完全捕捉肥胖对呼吸系统疾病死亡率的复杂影响,特别是在COPD中.
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