根据NHANES数据,心脏代谢指数与胆结石病和胰岛素抵抗的相关性
Liu Yuan1,2, Shuqi Wang2, Dong Wang2
1China Medical University, Shenyang, China.
BMC gastroenterology
|May 9, 2025
概括
心脏代谢指数 (CMI) 显示出与胆结石病 (GSD) 和胰岛素抵抗 (IR) 的非线性正相关性. CMI可能是代谢综合征,肥胖和GSD的有用指标.
科学领域:
- 代谢健康 代谢健康
- 心血管疾病风险因素 心血管疾病风险因素
- 胃肠道疾病 胃肠道疾病
背景情况:
- 心脏代谢指数 (CMI) 整合了内脏肥胖和脂质不良.
- 它与GSD患者的胆结石病 (GSD) 和胰岛素抵抗 (IR) 的关联需要进一步调查.
研究的目的:
- 检查CMI和GSD之间的关系.
- 阐明GSD患者中CMI和IR之间的关联.
主要方法:
- 限制立方线 (RCS) 分析以探索非线性关联.
- 多变量逻辑回归,子组分析和相互作用测试.
- 使用HOMA-IR和TyG指数评估IR;用于预测绩效的ROC曲线分析.
主要成果:
- 在CMI和GSD (P<0.001) 和CMI和IR (P<0.001) 之间发现了非线性正相关性.
- 高CMI显着与GSD (OR=1.547) 和IR (OR=4.990) 的风险增加有关.
- 与传统指标相比,CMI显示了GSD和IR的优异预测性能.
结论:
- CMI与GSD和IR发生率呈现非线性正相关性.
- CMI可以作为代谢综合征,肥胖和GSD的新型指标.
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