多种金属暴露与骨矿物质密度之间的关联:美国儿童和青少年的一项基于人口的研究
Jian Han1, Jiaqing Sun1, Lin Yuan1
1Wenyan Branch of the First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
BMC musculoskeletal disorders
|May 9, 2025
概括
这项研究发现,接触和铜等金属对儿童和青少年的骨矿物质密度 (BMD) 有负面影响,而则显示出积极的关联. 这些发现对于儿科人口的骨健康策略至关重要.
科学领域:
- 环境健康 环境健康
- 儿科毒理学 儿科毒理学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 环境暴露对儿童发育有很大的影响.
- 骨矿物质密度 (BMD) 是儿童和青少年时期骨健康的关键指标.
- 了解多金属暴露对儿科BMD的影响对于公共卫生至关重要.
研究的目的:
- 调查美国儿童和青少年接触各种金属和骨硬化之间的关联.
- 为了确定与腰部和全身 BMD 相关联的特定金属.
- 通过使用先进的统计模型,探索金属暴露之间的复杂相互作用.
主要方法:
- 来自2011-2016年国家健康和营养检查调查 (NHANES) 的1591名参与者 (8-19岁) 的数据分析.
- 测量血清中的铜 (Cu), (Se), (Zn) 和血液中的 (Pb), (Cd), (Hg) 和 (Mn).
- 使用双能X射线吸收计评估腰部和全骨 BMD,通过加权量子素和 (WQS) 回归和贝叶斯核机回归 (BKMR) 进行统计分析.
主要成果:
- 血液中的 (Pb) 和血清中的铜 (Cu) 与腰部 BMD 相反相关,而血清中的 (Se) 显示出正相关性.
- 权重定量总和 (WQS) 回归表明金属混合物与腰部和总骨损伤之间存在显著的关联,确定 (Cd),Se和 (Hg) 是主要贡献者.
- 贝叶斯核机器回归 (BKMR) 揭示了非线性暴露-反应关系和 (Cd) 和 (Mn) 之间的协同效应.
结论:
- 混合金属暴露对儿童和青少年的骨健康起着重要作用.
- 该研究强调,需要将多重金属暴露的评估纳入儿科骨健康评估.
- 研究结果为制定预防策略提供了关键的见解,以保护儿科患者骨发育.
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