用孕激素进行的卵巢刺激以冷保存卵细胞,非医疗适应症患者:一项病例对照研究
Ophélie Sounigo1,2, Léah Cohen Aloro1,2, Michael Grynberg1,2
1Department of Reproductive Medicine and Fertility Preservation, Universite Sorbonne Paris Nord, Assistance Publique- Hopitaux de Paris, Jean Verdier Hospital, Avenue du 14 juillet, Bondy, 93140, France.
Reproductive biology and endocrinology : RB&E
|May 9, 2025
概括
孕激素主导卵巢刺激 (PPOS) 协议与对抗者协议一样有效,用于卵细胞冷保存,产生类似的成熟卵细胞数量. PPOS提供了一种更方便,更为患者友好的方法,监测次数更少.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 孕激素主导卵巢刺激 (PPOS) 协议因其在预防黄素化激素 (LH) 激增的有效性而得到认可.
- 由于其简单性和成本效益,PPOS通常是社会卵细胞冷保存的首选方法.
研究的目的:
- 评估PPOS协议的有效性和方便性,以非医疗原因冷保存卵细胞.
- 在关键结果方面,比较PPOS与已建立的对抗剂协议.
主要方法:
- 一个双中心匹配的病例控制研究,比较PPOS周期与社会卵细胞冷保存的对手协议周期.
- 匹配是基于 antral 毛囊数量,BMI 和初始淋巴激素剂量.
- 主要终点是成熟卵细胞的数量;次要终点包括通过监测频率的便利性.
主要成果:
- 在PPOS和对抗剂协议之间,成熟 (MII) 卵子细胞或总检索卵子细胞 (COC) 的数量没有统计学上显著的差异.
- 这些组之间的成熟率和卵巢刺激指数 (OSI) 是可比的.
- 在PPOS协议组需要显著减少监测会议.
结论:
- 在具有非医疗适应症的患者中,PPOS协议的有效性与对抗者协议的卵细胞冷保存效果相当.
- PPOS提供了更为友好的患者体验,减少了监测,使其成为可行的第一线选择.
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