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Updated: May 15, 2025

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证据表明,微质细胞从神经元表达的APP产生粉样蛋白:一个假设

John Hardy1,2,3, Patrick Lewis4

  • 1Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. j.hardy@ucl.ac.uk.

Molecular neurodegeneration
|May 9, 2025
PubMed
概括

粉样蛋白前体蛋白 (APP) 主要存在于神经元中,但当受损的膜清除失败时,微细胞会产生粉样蛋白-β (Aβ) .

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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