胰岛素抵抗与多种慢性疾病之间的关联:来自CHARLS的横截面研究
Wen-Ze Jiang1, Zhen-Liang Fan2, Meng-Li Xu1
1The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Journal of health, population, and nutrition
|May 9, 2025
概括
胰岛素抵抗 (IR) 指数如TyG,TyG-BMI和METS-IR与更高的慢性疾病患病率有关. 改善IR可能会减少老年人的慢性疾病负担.
科学领域:
- 代谢健康 代谢健康
- 公共卫生 公共卫生
- 慢性疾病流行病学 慢性疾病流行病学
背景情况:
- 慢性疾病是一个重大的全球健康挑战.
- 胰岛素抵抗 (IR) 与许多慢性疾病的发展有关.
- 了解IR指数与慢性疾病之间的关系对于公共卫生战略至关重要.
研究的目的:
- 调查各种与胰岛素抵抗 (IR) 相关的指数与九种慢性疾病的患病率之间的关联.
- 评估这些IR指数对慢性疾病的预测能力.
- 探索这些关联中的子组变化.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的数据.
- 采用二进制物流回归和受限制立方 (RCS) 来分析关系.
- 进行了子组分析和接收器运行特征 (ROC) 曲线分析,以评估预测能力.
主要成果:
- 增加的TyG,TyG-BMI,TyG-WHtR和METS-IR指数与多种慢性疾病的患病率之间观察到一个积极的关联.
- 发现eGDR指数与慢性疾病患病率之间存在反向关系.
- 胰岛素耐药性指数显示出失脂症的最高预测准确度,TyG是最有效的预测因子.
结论:
- 胰岛素抵抗 (IR) 指数与多种慢性疾病的患病率呈正相关.
- 旨在改善中年和老年人群的IR的干预措施可能会减轻慢性疾病的负担.
- 这些发现强调了监测和管理IR对于预防慢性疾病的重要性.
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