多系统故障,临界点和阿尔茨海默病的风险
Simona Merlini1,2, Edward J Bedrick3,4, Roberta Diaz Brinton1,5,6
1Center for Innovation in Brain Science, University of Arizona Health Sciences, Tucson, Arizona, USA.
概括
阿尔茨海默病 (AD) 风险因素的持续时间,如肥胖和糖尿病,显著影响发病,有时比APOEε4基因型更大. 关键的与年龄相关的临界点,特别是在62-72岁之间,揭示了AD进展的动态.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 肥胖,糖尿病,高脂血症和抑郁症等医疗状况是已知的阿尔茨海默病 (AD) 的风险因素.
- 这些风险因素的持续时间以及性别和阿波利波蛋白E (APOE) 基因型等不可修改因素对阿尔茨海默病风险的影响仍然不完全理解.
研究的目的:
- 调查常见疾病持续时间对阿尔茨海默病 (AD) 风险的影响.
- 为了确定AD风险因子发病的关键年龄相关的临界点.
- 为了检查风险因素持续时间与性别和APOE基因型在AD病变发生的相互作用.
主要方法:
- 分析了来自5644名英国生物库参与者的数据.
- 利用考克斯回归建模来确定关键的临界点.
- 检查了发病年龄,危险因素持续时间,性别和APOE基因型的相互作用.
主要成果:
- 在62岁之前诊断的高血压或糖尿病比单独的APOEε4基因型具有更大的AD风险.
- 在62岁之前的肥胖增加了AD风险54%,在62-72岁之间风险几乎增加了三倍.
- 超脂血症和抑郁症的年龄独立风险增加分别为33%和69%. 在72岁以后,APOEε4成为主要的风险因素.
结论:
- 患AD风险因素的持续时间可能比APOEε4基因型对AD发作的影响更大.
- 关键的与年龄相关的临界点,特别是在62岁和72岁之间,突出了AD进展的时间性质.
- 多系统衰竭和不同的遗传轨迹 (APOEε4携带者与非携带者) 在不同性别的阿尔茨海默病发展中发挥着重要作用.
关键词:
预防AD的策略和预防策略.其他AD风险因素这是APOE基因型.阿尔茨海默病 (AD) 是一种疾病.考克斯的比例危险模型 (CPHM)英国生物银行染色体上的性别.抑郁 抑郁症 抑郁症 抑郁症 抑郁症超脂血症 (HLP) 是一种高脂血症.高血压 (HTN) 是指高血压.晚期发病的阿尔茨海默氏病 (LOAD)可以修改的风险因素.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖第二种类型糖尿病 (T2D)不能改变的风险因素更多相关视频
09:45Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
10.1K
06:23Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
Published on: October 30, 2018
7.9K
相关概念视频
01:26Alzheimer's Disease: Overview
328
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
328
01:30Dementia
73
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
73
01:22Alzheimer's Disease: Treatment
128
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
128
03:03Amyloid Fibrils
9.1K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.1K
01:26Aging
26
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
26
01:29Psychological and Sociocultural Causes of Schizophrenia
33
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
33