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相关实验视频

Updated: Jun 16, 2026

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder
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优化碎片化,同时最大限度地降低热伤害风险,在尿道石的石质:一个体外研究中的图纤维激光.

Arpit Mishra1, Ezra J Margolin2, Aaron W Stewart2

  • 1Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA.

Journal of endourology
|May 10, 2025
PubMed
概括

优化纤维激光器 (TFL) 设置对于安全有效的尿路石块碎片化至关重要. 低功率设置 (10W) 与适当的灌将热损伤风险降至最低,同时实现高效的石头清除.

关键词:
碎片化 碎片化 碎片化灌流量是指灌的流量.热伤害的伤害是由于热伤害造成的.thulium光纤激光器的使用方法尿路结石 尿路结石

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 激光医学是激光医学.
  • 生物医学工程 生物医学工程

背景情况:

  • 尿道结石的治疗通常涉及激光石.
  • 在狭窄的尿路空间中,在图纤维激光 (TFL) 程序中最大限度地减少热损伤是一个重大的临床挑战.
  • 优化激光参数对于平衡石块碎片效率和患者安全至关重要.

研究的目的:

  • 为了确定最佳的纤维激光器 (TFL) 设置,以有效地进行尿道石块碎片化.
  • 评估和最大限度地降低与在模拟的尿路环境中使用TFL相关的热伤害风险.
  • 调查灌参数对温度和处理结果的影响.

主要方法:

  • 使用基于水凝的三维尿管模型,保持体温.
  • 贝戈斯通的幻影模拟了尿道石头.
  • 图纤维激光器 (TFL) 的参数 (功率,频率,脉冲能量) 和灌 (速率,温度) 系统地变化.
  • 最大持续温度 (MST) 和累积热剂量与120分钟的安全值相比进行了测量.
  • 通过测量经过处理的石头质量来评估石头碎片化效率.

主要成果:

  • 在6.4W和10WTFL设置下,MST保持在体温以下,热剂量最小 (<1分钟),表明热风险低.
  • 在20W的20毫升/分钟灌下,MST迅速超过43°C,热剂量超过了120分钟的安全门.
  • 治疗效率在20W (1.58毫克/秒) 最高,其次是10W (1.15毫克/秒) 和6.4W (0.78毫克/秒).
  • 使用1.0 J/10 Hz的10W设置比2.0 J/5 Hz或3.0 J/3 Hz更有效.
  • 安全设置 (10W) 产生了95.5%的微尘,而更高能量的脉冲 (2-3 J) 则产生了更多更大的碎片.
  • 增加灌 (40毫升/分钟) 或冷灌 (15°C) 减少了MST和提高了效率,特别是在20W.

结论:

  • 高功率的TFL处理 (20W) 在尿道空间中存在严重的热损伤风险.
  • 10W的TFL设置,特别是2.0J/5Hz的适当灌,为尿道石块碎片化提供了安全有效的选择.
  • 对这些优化的设置进行进一步的临床验证对于人类石头治疗是有必要的.